Congratulations to Gary Tang from the Campopiano group on publishing his first paper in none other than the high-impact Journal of Dental Reesearch.
The paper is titled "Porphyromonas gingivalis Sphingolipid Synthesis Limits the Host Inflammatory Response."
We have studied the structure and mechanism of the enzyme serine palmitoyl transferase (SPT) for many years. This new paper describes how SPT is important in sphingolipid biosynthesis in the dental pathogen Porphyromonas gingivalis. It turns out that P. gingivalis sphingolipids mediate the host inflammatory response and without them, this pathogen is highly inflammatory to human cells.
This work was carried out in in collaboration with Prof. Mary-Ellen Davey's group in Florida.