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New Research From The Thomas Group

Paper published in ACS Catalysis
Table of contents image from the article

A new research paper from the Thomas group titled "A Boron-Oxygen Transborylation Strategy for a Catalytic Midland Reduction" has been accepted for publication in the journal ACS Catalysis.

Since their introduction over 50-years ago enantioenriched boranes have become ubiquitous in asymmetric synthesis. The Midland reduction offers a simple and highly effective means for the asymmetric reduction of ketones, but remains a stoichiometric process. Using a new mechanism for catalyst turnover, transborylation, the research team rendered the Midland reduction catalytic. This exemplar use of transboryaltion paves the way for greater exploitation and the development wider main-group catalysis protocols.

Tuesday, January 26, 2021