Research carried out by Professor Colin Campbell's group, with collaborators in the University of Edinburgh's School of Biology, Jerusalem and Liege has recently been published online in the Proceedings of theNational Academy of Sciences of the United States of America. The paper is titled "Intracellular redox potential is correlated with miRNA expression in MCF7 cells under hypoxic conditions ".
Research carried out through a collaboration between Brown University, SLAC, and the Kirrander group in the School of Chemistry demonstrates how deep UV light can trigger ground state chemical reactions that can be tracked using ultrafast x-rays.
Prof Colin Pulham and Dr Sumit Konar from the School of Chemistry recently collaborated with University College London and Eli Lilly and Company on a paper that has now been accepted in JACS. The paper details research that comnbined multiple methods to find the crystal structures of all 10 unsolvated polymorphs of galunisertib, which is currently undergoing trials as a cancer drug.
Dr Adam Kirrander and his team have published a paper in Nature Chemistry with collaborators at Brown University and the SLAC National Accelerator Laboratory. The experiment exploits the brightness and high time resolution of the new x-ray free-electron laser, LCLS in California, to capture the vibrational motion of an excited molecule in detail.
Research involving Professor Polly Arnold's group has been highlighted by Chemistry World. The research was part of a collaboration funded by the UK catalysis hub.
The paper reports on a new system that uses a di-zinc catalyst to recycle waste carbon dioxide from one reaction into another.
This month's Nature Chemistry cover image is taken from research by the Kirrander group. The image features in an article entitled "The photochemical ring-opening of 1,3-cyclohexadiene imaged by ultrafast electron diffraction".
The paper is the result of a collaboration between scientists from SLAC and Stanford, Edinburgh and Brown Universities.
The McKeown group’s paper on stabilising a porous molecular crystal using fullerenes and showing, by in-situ crystallography, reactions at open metal sites has now been published in Nature Materials. The paper is titled "Highly stable fullerene-based porous molecular crystals with open metal sites".
The Campopiano group have published a paper in the May issue of JLR where they describe the kinetics differences between the human and bacterial forms of serine palmitoyltransferase (SPT) - the first enzyme in sphingolipid biosynthesis.
The paper is also the first publication between the University of Edinburgh and The Rosalind Franklin Institute (RFI) in collaboration with RFI Director Prof. Jim Naismith.