Dr Scott L. Cockroft
Physical Organic Chemistry
By studying the properties and behaviour of intramolecular and supramolecular systems in a systematic way, we seek to investigate the fundamental phenomena governing non-covalent interactions and chemical reactivity; i.e. the key determinants of structure and activity in chemical and biological systems.
Single-molecule studies of molecular machines and enzymes
We are developing nanopore-based biophysical approaches for monitoring the activity and conformational dynamics of molecular machines and enzymes in real-time. The method works on the principle that conformational changes in a single macromolecule held near (or threaded through) a transmembrane protein pore will induce tiny (but detectable) changes in the ion current flowing through the pore under an applied transmembrane potential (voltage).
- Quantifying solvophobic effects in non-polar cohesive interactions L. Yang, C. Adam & S. L. Cockroft*. J. Am. Chem. Soc. doi: 10.1021/jacs.5b05736 (2015).
- Partitioning solvophobic & dispersion forces in alkyl and perfluoroalkyl cohesion C. Adam, L. Yang & S. L. Cockroft*. Angew. Chem. Int. Ed. 54(4), 1164–1167 (2015).
- How much do van der Waals dispersion forces contribute to molecular recognition in solution? L. Yang, C. Adam, G. S. Nichol & S. L. Cockroft*. Nature Chem. 5(12), 1006–1010 (2013). Featured in: Nature Chem. News & Views | Chemistry World | C&EN | 'In The Pipeline' Blog
- Electrostatic modulation of aromatic rings via explicit solvation of substituents K. B. Muchowska, C. Adam, I. K. Mati & S. L. Cockroft*. J. Am. Chem. Soc. 135, 9976–9979 (2013).
- Aromatic reactivity revealed: beyond resonance theory & frontier orbitals J. J. Brown & S. L. Cockroft*. Chem. Sci. 4, 1772–1780 (2013).