Rare-earth element dependent technologies are crucial for renewable energy generation and storage, electric vehicles, and electronic displays. However, access to these metals, in large part due to difficulties in their separation, is limited and is dominated by China. Improving how rare-earth elements are separated is essential to prevent metal supply derailing climate efforts.
Congratulations to MChem Medicinal and Biological Chemistry alumnus, Marek Varga, for being published in Science.
Marek contributed to the recently published paper, “Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function”. His collaborators included researchers from our partner institution Karolinska Institutet, where Marek completed his final year overseas placement in July 2021 as part of the Helleday Laboratory.
Hydrogen bonds are everywhere. They determine the structure and properties of water and materials. In life, hydrogen bonds govern the structure of proteins, DNA, RNA, and their associated molecular recognition processes. Clearly, biology has mastered the use of hydrogen bonds, yet such interactions occur in the presence of one of the most competitive hydrogen bonding solvents known; water. However, water is such a good hydrogen bond donor and acceptor that the energy of a single hydrogen bond is effectively nullified by the competing interactions with the solvent.
New publication by Fabio Nudelman highlights findings on how the strength of bone is enhanced due to prestresses that are generated at the nanoscale.
The Campopiano and Lawrence groups have published a new amine donor for biocatalysis, inspired by nature and broadly applicable, which could open up greener and more sustainable alternatives to the metal-catalysed methods for synthesis of chiral amines that are currently used across the pharmaceutical, agrochemical and fine chemical industries. They also made the front cover of the journal!
Recent work from the Ingleson group developed the first examples of simple boron based compounds (organoboranes) as phase transfer catalysts for nucleophilic fluorination to form C-F bonds using inexpensive CsF as the fluoride source.
Congratulations to the Jarvis group on their first foray into cyclic peptides: Macrocylases as synthetic tools for ligand synthesis: enzymatic synthesis of cyclic peptides containing metal-binding amino acids, which was published in Royal Society Open Science.
Congratulations to the team including recent Jarvis group alumni Dr Richard Brewster,
The Garden group have had their work on divalent heterometallic catalysts for lactide polymerisation published in Catalysis Sci Tech.
Experiments were led by Garden Group PhD student Weronika Gruszka. Her PhD research focuses on the synthesis of novel homo- and hetero-metallic complexes for the ring-opening polymerisation of cyclic esters as part of the EPSRC CRITICAT Centre for Doctoral Training. Recent MChem graduate Haopeng Sha & DFT Antoine Buchard also give insight in to heterometallic cooperativity.
In research funded by the ERC and now reported in the Journal of the American Chemical Society, Dr Michael Cowley and postdoctoral researcher Dr Andryj Borys have developed a new and widely applicable synthetic route to a broad class of compounds called phospha-alkenes.