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Featured Publications

Chemical ‘Egg-boxes’ Could Crack Rare-earth Element Separations

Rare-earth element dependent technologies are crucial for renewable energy generation and storage, electric vehicles, and electronic displays. However, access to these metals, in large part due to difficulties in their separation, is limited and is dominated by China. Improving how rare-earth elements are separated is essential to prevent metal supply derailing climate efforts.

Recent Graduate Published in Science

Congratulations to MChem Medicinal and Biological Chemistry alumnus, Marek Varga, for being published in Science.

Marek contributed to the recently published paper, “Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function”. His collaborators included researchers from our partner institution Karolinska Institutet, where Marek completed his final year overseas placement in July 2021 as part of the Helleday Laboratory.

Angewandte Chemie Hot Paper

Hydrogen bonds are everywhere. They determine the structure and properties of water and materials. In life, hydrogen bonds govern the structure of proteins, DNA, RNA, and their associated molecular recognition processes. Clearly, biology has mastered the use of hydrogen bonds, yet such interactions occur in the presence of one of the most competitive hydrogen bonding solvents known; water. However, water is such a good hydrogen bond donor and acceptor that the energy of a single hydrogen bond is effectively nullified by the competing interactions with the solvent.

N-Phenylputrescine (NPP): A Natural Product Inspired Amine Donor for Biocatalysis

The Campopiano and Lawrence groups have published a new amine donor for biocatalysis, inspired by nature and broadly applicable, which could open up greener and more sustainable alternatives to the metal-catalysed methods for synthesis of chiral amines that are currently used across the pharmaceutical, agrochemical and fine chemical industries. They also made the front cover of the journal!

Jarvis Group Article Published in Royal Society Open Science

Congratulations to the Jarvis group on their first foray into cyclic peptides: Macrocylases as synthetic tools for ligand synthesis: enzymatic synthesis of cyclic peptides containing metal-binding amino acids, which was published in Royal Society Open Science.

Congratulations to the team including recent Jarvis group alumni Dr Richard Brewster,

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Garden Group Paper Published in Catalysis Sci and Tech

The Garden group have had their work on divalent heterometallic catalysts for lactide polymerisation published in Catalysis Sci Tech.

Experiments were led by Garden Group PhD student Weronika Gruszka. Her PhD research focuses on the synthesis of novel homo- and hetero-metallic complexes for the ring-opening polymerisation of cyclic esters as part of the EPSRC CRITICAT Centre for Doctoral Training. Recent MChem graduate Haopeng Sha & DFT Antoine Buchard also give insight in to heterometallic cooperativity.